UNC 3230

A selective PIP5K1C inhibitor

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库存: 现货

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价格

促销价

数量
5mg

￥1412.00

1130.00

- +
10mg

￥2175.00

1740.00

- +
50mg

￥7550.00

6040.00

- +
100mg

￥10575.00

8460.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajci10350
CAS: 1031602-63-7
别名:
分子式: C17H20N4O2S
分子量: 344.43
纯度: >98%
溶解度: 0.2mg/mL in ethanol, 30mg/mL in DMSO, or in DMF
储存: Store at -20°C
库存: 现货

Background

Phosphatidylinositol-4-phosphate 5-kinase type-1 γ (PIP5K1C) is a lipid kinase that generates phosphatidylinositol-4,5-bisphosphate (PIP2) in nociceptive dorsal root ganglia (DRG).[1] Pain sensitization is regulated by multiple signaling pathways that are initiated by phospholipase C-mediated hydrolysis of PIP2.[1] UNC3230 is a small molecule inhibitor of PIP5K1C (IC50 = 41 nM, Kd = 51 nM).[1] It does not inhibit any other lipid kinases that regulate phosphoinositide levels, including phosphatidylinositol 3-kinases.[1] At 100 nM, UNC3230 decreases PIP2 membrane levels in cultured DRG neurons by 45% and significantly reduces calcium signaling. At 2 nM, it displays antinociceptive effects in mouse models of chronic pain when administered intrathecally or injected into inflamed hindpaw.[1]

Reference:
[1]. Wright, B.D., Loo, L., Street, S.E., et al. The lipid kinase PIP5K1C regulates pain signaling and sensitization. Neuron 82(4), 836-847 (2014).