Naspm trihydrochloride

A synthetic analog of Joro spider toxin

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10mg

￥1462.00

1170.00

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货号: ajci10940
CAS: 1049731-36-3
别名: N-[3-[[4-[(3-氨基丙基)氨基]丁基]氨基]丙基]-1-萘乙酰胺三盐酸盐,1-Naphthylacetyl spermine trihydrochloride
分子式: C22H34N4O.3HCl
分子量: 479.91
纯度: >98%
溶解度: DMSO: 1.7 mg/mL,PBS (pH 7.2): 10 mg/mL
储存: Store at -20°C
库存: 现货

Background

Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.

NASPM selectively suppresses the inwardly rectifying and Ca2+-permeable AMPA receptors expressed in type II neurons. It has no effect on AMPA receptors in type I neurons. At -60 mV, NASPM suppresses AMPA receptors in type II neurons with an IC50 value of 0.33 μM. The blocking effect of NASPM on the Ca2+-permeable AMPA receptors is use and voltage-dependent[1].

参考文献:
[1]. Koike M, et al. Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons. Neurosci Res. 1997 Sep;29(1):27-36.