Triflurdine (Viroptic)

A thymidine analog that inhibits DNA synthesis

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
50mg

￥637.00

510.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajci11848
CAS: 70-00-8
别名: 曲氟尿苷; Trifluorothymidine; 5-Trifluorothymidine; TFT
分子式: C10H11F3N2O5
分子量: 296.2
纯度: >98%
溶解度: ≥ 14.45mg/mL in DMSO
储存: Store at -20°C
库存: 现货

Background

Trifluridine (Trifluorothymidine; 5-Trifluorothymidine; TFT) is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Trifluridine is an antiviral drug for herpes simplex virus (HSV) infection.

参考文献:
[1]. Suzuki N, et al. Mode of action of trifluorothymidine (TFT) against DNA replication and repair enzymes. Int J Oncol. 2011 Jul;39(1):263-70.
[2]. Suzuki N, et al. Trifluorothymidine exhibits potent antitumor activity via the induction of DNA double-strand breaks. Exp Ther Med. 2011 May;2(3):393-397.
[3]. Temmink OH, et al. Irinotecan-induced cytotoxicity to colon cancer cells in vitro is stimulated by pre-incubation withtrifluorothymidine. Eur J Cancer. 2007 Jan;43(1):175-83.
[4]. Okayama T, et al. Involvement of concentrative nucleoside transporter 1 in intestinal absorption of trifluorothymidine, a novel antitumor nucleoside, in rats. J Pharmacol Exp Ther. 2012 Feb;340(2):457-62.