N-Arachidonylglycine

A metabolite of anandamide with analgesic activity

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5mg

￥600.00

480.00

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10mg

￥1025.00

820.00

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25mg

￥2275.00

1820.00

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50mg

￥3350.00

2680.00

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100mg

￥5450.00

4360.00

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货号: ajci13742
CAS: 179113-91-8
别名: N-Arachidonyl Glycine, NAGly
分子式: C22H35NO3
分子量: 361.52
纯度: >98%
溶解度: 50mg/mL in ethanol, 10mg/mL in metyle acetate, 15mg/mL in DMSO, 20mg/mL in DMSO
储存: Store at -80°C
库存: 现货

Background

Arachidonoyl glycine (N-arachidonyl glycine; NAGly) has been isolated from cell cultures treated with arachidonoyl ethanolamide (AEA; anandamide),1 from extracts of mammalian brain,2,3 and has also been synthesized as an analog of AEA for structure/activity testing.4 NAGly may be produced endogenously via oxidation of AEA, or by transacylation of arachidonoyl CoA. NAGly is reported to have analgesic activities in whole animal experiments.[1],[2],[3] Since it seems to be a very poor ligand for the CB1 receptor,[4] these effects are probably mediated via other signaling pathways.

Reference:
[1]. Burstein, S.H., Rossetti, R.G., Yagen, B., et al. Oxidative metabolism of anandamide. Prostaglandins & Other Lipid Mediators 61, 29-41 (2000).
[2]. Huang, S.M., Bisogno, T., Petros, T.J., et al. Identification and characterization of an endogenous anandamide-like compound: N-arachidonylglycine (NAGly). ICRS 2001 Symposium on the Cannabinoids 78 (2001).
[3]. Huang, S.M., Bisogno, T., Petros, T.J., et al. Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain. The Journal of Biological Chemisty 276(46), 42639-42644 (2001).
[4]. Sheskin, T., Hanus, L., Slager, J., et al. Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptor. Journal of Medicinal Chemistry 40, 659-667 (1997).