Etifoxine hydrochloride

A positive allosteric modulator of GABAA receptors

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库存: 现货

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5mg

￥762.00

610.00

- +
10mg

￥1050.00

840.00

- +
50mg

￥3662.00

2930.00

- +
100mg

￥6587.00

5270.00

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已选 0 种 0 瓶

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货号: ajci14770
CAS: 56776-32-0
别名: 盐酸艾替伏辛,Stresam;HOE 36-801
分子式: C17H18Cl2N2O
分子量: 337.24
纯度: >98%
溶解度: ≥ 33.7 mg/mL in DMSO with gentle warming, ≥ 48.1 mg/mL in EtOH with gentle warming, ≥ 15.49 mg/mL in Water with gentle warming
储存: Store at -20°C
库存: 现货

Background

Etifoxine hydrochloride (HOE 36-801 hydrochlorid) is potentiator of GABAA receptor function in cultured neurons. Etifoxine preferentially acts on β2 or β3 subunit-containing GABAA receptors. IC50 value:Target: GABAA receptorEtifoxine exhibits anxiolytic activity in rodents and humans with no sedative, myorelaxant or mnesic side effects. Etifoxine acts as a ligand of the translocator protein (TSPO); promotes axonal regeneration.

参考文献:
[1]. Verleye M, Dumas S, Heulard I, et al. Differential effects of etifoxine on anxiety-like behaviour and convulsions in BALB/cByJ and C57BL/6J mice: any relation to overexpression of central GABAA receptor beta2 subunits Eur Neuropsychopharmacol. 2011 Jun;21(6):457-70.
[2]. Bourin M, Hascot M. Implication of 5-HT2 receptor subtypes in the mechanism of action of the GABAergic compound etifoxine in the four-plate test in Swiss mice. Behav Brain Res. 2010 Apr 2;208(2):352-8.
[3]. Gee KW, Tran MB, Hogenkamp DJ, et al. Limiting activity at beta1-subunit-containing GABAA receptor subtypes reduces ataxia. J Pharmacol Exp Ther. 2010 Mar;332(3):1040-53.
[4]. Aouad M, Charlet A, Rodeau JL, et al. Reduction and prevention of vincristine-induced neuropathic pain symptoms by the non-benzodiazepine anxiolytic etifoxine are mediated by 3alpha-reduced neurosteroids. Pain. 2009 Dec 15;147(1-3):54-9.
[5]. Girard C, Liu S, Cadepond F, et al. Etifoxine improves peripheral nerve regeneration and functional recovery. Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20505-10.