Rabeprazole

雷贝拉唑 (LY307640) 是第二代质子泵抑制剂 (PPI)，可不可逆地灭活胃 H+/K+-ATPase。

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库存: 现货

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10mg

￥462.00

370.00

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货号: ajci17532
CAS: 117976-89-3
别名: 雷贝拉唑; LY307640
分子式: C18H21N3O3S
分子量: 359.44
纯度: >98%
溶解度: ≥ 12.65mg/mL in DMSO
储存: Store at -20°C, stored under nitrogen
库存: 现货

Background

Rabeprazole is an antiulcer drug in the class of proton pump inhibitors.Target: Proton PumpRabeprazole belongs to a class of antisecretory compounds (substituted benzimidazole proton-pump inhibitors) that do not exhibit anticholinergic or histamine H2-receptor antagonist properties, but suppress gastric acid secretion by inhibiting the gastric H+/K+ATPase (hydrogen-potassium adenosine triphosphatase) at the secretory surface of the gastric parietal cell. Because this enzyme is regarded as the acid (proton) pump within the parietal cell, rabeprazole has been characterized as a gastric proton-pump inhibitor. Rabeprazole blocks the final step of gastric acid secretion. In gastric parietal cells, rabeprazole is protonated, accumulates, and is transformed to an active sulfenamide. When studied in vitro, rabeprazole is chemically activated at pH 1.2 with a half-life of 78 seconds.

参考文献:
[1]. http://www.drugbank.ca/drugs/DB01129