U 73343

An inactive analog of U-73122

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库存: 现货

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1mg

￥312.00

250.00

- +
5mg

￥925.00

740.00

- +
10mg

￥1537.00

1230.00

- +
25mg

￥3437.00

2750.00

- +

已选 0 种 0 瓶

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货号: ajci20162
CAS: 142878-12-4
别名:
分子式: C29H42N2O3
分子量: 466.66
纯度: >98%
溶解度: 0.25mg/ml in ethanol; 0.5mg/ml in DMSO; 2mg/ml in DMF
储存: Store at -20°C
库存: 现货

Background

U-73122 is an inhibitor of PLC-dependent processes, however, the mechanism of action remains unclear.[1],[2],[3] The IC50 values for inhibition of platelet aggregation induced by collagen or thrombin are 0.6 and 5 μM, respectively.2 It also exhibits inhibitory activity against HIV-1 integrase with an IC50 value of 7 μM.[4] U-73343 is a close structural analog of U-73122 that does not inhibit PLC, making it useful as a negative control for PLC inhibition.[1]

Reference:
[1]. Smith, R.J., Sam, L.M., Justen, J.M., et al. Receptor-coupled signal transduction in human polymorphonuclear neutrophils: Effects of a novel inhibitor of phospholipase C-dependent processes on cell responsiveness. Journal of Pharmacology and Experimental Therapeutics 253, 688-697 (1990).
[2]. Bleasdale, J.E., Thakur, N.R., Gremban, R.S., et al. Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils. Journal of Pharmacology and Experimental Therapeutics 255, 756-768 (1990).
[3]. Hildebrandt, J.P., Plant, T.D., and Meves, H. The effects of bradykinin on K+ currents in NG108-15 cells treated with U73122, a phospholipase C inhibitor, or neomycin. British Journal of Pharmacology 120, 841-850 (1997).
[4]. Burke, T.R., Jr., Fesen, M.R., Mazumder, A., et al. Hydroxylated aromatic inhibitors of HIV-1 integrase. Journal of Medicinal Chemistry 38, 4171-4178 (1995).