An activator of glycogen phosphorylase b
N6-Methyladenosine 5'-monophosphate is an activator of glycogen phosphorylase b (Ka = 22 μM).[1] It is also a non-competitive inhibitor of rat adenylate kinase II (Ki = 4.2 mM).[2] N6-Methyladenosine 5’-monophosphate (sodium salt) has been used for immunoprecipitation of N6-methyladenosine.[3]
Reference:
[1]. Morange, M., García Blanco, F., Vandenbunder, B., et al. AMP Analogs : Their function in the activation of glycogen phosphorylase b. Eur. J. Biochem. 65(2), 553-563 (1976).
[2]. Hai, T.T., Picker, D., Abo, M., et al. Species- or isozyme-specific enzyme inhibitors. 7. Selective effects in inhibitions of rat adenylate kinase isozymes by adenosine 5’-phosphate derivatives. J. Med. Chem. 25(7), 806-812 (1982).
[3]. Fry, N.J., Law, B.A., Ilkayeva, O.R., et al. N6-methyladenosine is required for the hypoxic stabilization of specific mRNAs. RNA 23(9), 1444-1455 (2017).
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