CU-CPT8m

A TLR8 antagonist

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
1mg

￥0.00

0.00

- +
5mg

￥1337.00

1070.00

- +
10mg

￥2125.00

1700.00

- +
25mg

￥0.00

0.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajci20854
CAS: 125079-83-6
别名: TLR8-specific antagonist
分子式: C14H12N4O
分子量: 252.3
纯度: >98%
溶解度: Chloroform: 5 mg/ml,DMF: 0.2 mg/ml,DMSO: 0.2 mg/ml,Ethanol: slightly soluble
储存: Store at -20°C
库存: 现货

Background

CU-CPT8m is an antagonist of toll-like receptor 8 (TLR8; Kd = 220 nM; IC50 = 67 nM in a reporter assay). It is selective for TLR8 over a panel of all other human TLRs when used at a concentration of 1 μM. CU-CPT8m (1 μM) inhibits increases in TNF-α and IL-8 mRNA expression induced by the TLR8 agonist R-848 in TLR8-overexpressing HEK-Blue cells. It also inhibits R-848-induced increases in TNF-α protein levels in differentiated THP-1 monocytes and human primary peripheral blood mononuclear cells (PBMCs) in a concentration-dependent manner. CU-CPT8m decreases TNF-α and IL-8 levels in synovial cells derived from patients with osteoarthritis and TNF-α levels in PBMCs derived from patients with rheumatoid arthritis.