1,2-Dioleoyl-3-dimethylammonium-propane

An ionizable cationic lipid

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库存: 现货

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5mg

￥325.00

260.00

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10mg

￥612.00

490.00

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50mg

￥1962.00

1570.00

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100mg

￥2500.00

2000.00

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货号: ajci20946
CAS: 127512-29-2
别名: 18:1 DAP
分子式: C41H77NO4
分子量: 648.1
纯度: >98%
溶解度: Slightly Soluble in Chloroform, Slightly Soluble in Methanol
储存: Store at -20°C
库存: 现货

Background

1,2-Dioleoyl-3-dimethylammonium-propane (DODAP) is a cationic lipid. It has been used as a component in liposomes that can be used to encapsulate siRNA, immunostimulatory oligodeoxynucleotides, antisense oligonucleotides, or chemotherapeutic agents for in vitro and in vivo delivery. [1][2][3]

Reference:
[1]. Dabbas, S., Kaushik, R.R., Dandamudi, S., et al. Importance of the liposomal cationic lipid content and type in tumor vascular targeting: Physicochemical characterization and in vitro studies using human primary and transformed endothelial cells. Endothelium 15(4), 189-201 (2008).
[2]. Hamzah, J., Altin, J.G., Herringson, T., et al. Targeted liposomal delivery of TLR9 ligands activates spontaneous antitumor immunity in an autochthonous cancer model. J. Immunol. 183(2), 1091-1098 (2009).
[3]. Mendon?a, L.S., Firmino, F., Moreira, J.N., et al. Transferrin receptor-targeted liposomes encapsulating anti-BCR-ABL siRNA or asODN for chronic myeloid leukemia treatment. Bioconjug. Chem. 21(1), 157-168 (2010).