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  • MONNA
MONNA的可视化放大

MONNA

A selective inhibitor of ANO1A selective inhibitor of ANO1 A selective inhibitor of ANO1

原价
¥312-3775
价格
250-3020
MONNA的二维码

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  • 货号: ajci20958
  • CAS: 1572936-83-4
  • 别名: 2-(4-甲氧基萘-2-基氨基)-5-硝基苯甲酸
  • 分子式: C18H14N2O5
  • 分子量: 338.3
  • 纯度: >98%
  • 溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml,Ethanol: slightly soluble
  • 储存: Store at -20°C
  • 库存: 现货

Background

MONNA is a selective inhibitor of anoctamin-1 (ANO1; IC50 = 0.08 uM in Xenopus oocytes), a calcium-activated chloride channel (CaCC). It is selective for ANO1 over the chloride channels bestrophin-1, chloride channel protein 2, and cystic fibrosis transmembrane conductance regulator up to 10 uM. MONNA (10 uM) induces full vasorelaxation of preconstricted mouse isolated mesenteric arteries in the presence or absence of chloride. It also hyperpolarizes isolated rat mesenteric arteries under resting conditions.

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