安捷凯生物医药
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  • 5,6-dihydro-5-Fluorouracil
5,6-dihydro-5-Fluorouracil的可视化放大

5,6-dihydro-5-Fluorouracil

A metabolite of 5-FU

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5,6-dihydro-5-Fluorouracil的二维码
  • 库存: 现货
可选规格
  • 包装
    价格
    促销价
    数量
  • 5mg
    ￥1450.00
    1160.00
    - +
  • 10mg
    ￥2725.00
    2180.00
    - +
  • 25mg
    ￥6400.00
    5120.00
    - +
  • 50mg
    ￥11950.00
    9560.00
    - +
已选 0 种 0 瓶
金额: ￥0.00
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使用我司产品发表的文章

  • 货号: ajci21326
  • CAS: 696-06-0
  • 别名: 5-氟二氢嘧啶-2,4-二酮
  • 分子式: C4H5FN2O2
  • 分子量: 132.1
  • 纯度: >98%
  • 溶解度: DMF: 60 mg/ml,DMSO: 53 mg/ml,Ethanol: 0.8 mg/ml,PBS (pH 7.2): 8 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

5,6-dihydro-5-Fluorouracil (5-FUH2) is formed by the hydrogenation of 5-fluorouracil via the enzyme dihydropyrimidine dehydrogenase (DPD). Formulations containing 5-FU are used for the treatment of cancer. However, in patients lacking full DPD activity, severe adverse events, including death, can occur. 5-FUH2 is less toxic than 5-FU but is not as effective (IC50s = 3.3 and 560 uM for 5-FU and 5-FUH2, respectively in WiDr human colon cancer cells).

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