An N-terminal fragment of CCK
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CCK (26-31) is an N-terminal fragment of CCK , a peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety. The sulfated form of CCK (26-31) inhibits binding of [125I]CCK-33 to guinea pig cortical membranes by 21% when used at a concentration of 0.1 mM.
参考文献:
[1]. 1. Raybould, H.E., and Lloyd, K.C. Integration of postprandial function in the proximal gastrointestinal tract. Role of CCK and sensory pathways Ann. N.Y. Acad. Sci. 713(1), 143-156 (1994).
[2]. Ondetti, M.A., Plu??ec, J., Sabo, E.F., et al. Synthesis of cholecystokinin-pancreozymin. I. The C-terminal dodecapeptide J. Am. Chem. Soc. 92(1), 195-199 (1970).
[3]. Knight, M., Tamminga, C.A., Steardo, L., et al. Cholecystokinin-octapeptide fragments: Binding to brain cholecystokinin receptors Eur. J. Pharmacol. 105(1-2), 49-55 (1984).
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