ML-290

An RXFP1 agonist

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库存: 现货

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1mg

￥625.00

500.00

- +
5mg

￥2025.00

1620.00

- +
10mg

￥3437.00

2750.00

- +

已选 0 种 0 瓶

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货号: ajci21430
CAS: 1482500-76-4
别名: RXFP1 Agonist 8??
分子式: C24H21F3N2O5S
分子量: 506.5
纯度: >98%
溶解度: 0.14mg/mL in ethanol, 25mg/mL in DMSO, 30mg/mL in DMF
储存: Store at -20°C
库存: 现货

Background

ML-290 is an allosteric agonist of relaxin family peptide receptor 1 (RXFP1; EC50 = 94 nM for human RXFP1).[1],[2] It displays >15-fold selectivity for RXFP1 over RXFP2.[2] ML-290 activates human, rhesus macaque, pig, and rabbit RXFP1 but is weak or inactive at mouse or guinea pig RXFP1.[2],[3] Through RXFP1, ML-290 increases intracellular cAMP and induces VEGF expression (2.8-fold at 250 nM).[2] ML-290 is metabolically stable and displays excellent in vivo pharmacokinetics.[2]

Reference:
[1]. Paredes, R.M., Etzler, J.C., Watts, L.T., et al. Chemical calcium indicators. Methods 46(3), 143-151 (2008).
[2]. Minta, A., Kao, J.P., and Tsien, R.Y. Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophores. The Journal of Biological Chemisty 264(14), 8171-8178 (1989).