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Background:
SNVP is an S-nitrosothiol that acts as a nitric oxide (NO) donor and vasodilator. It decompensates to release NO in vitro, an effect that is enhanced by both CuSO4 and cysteine. SNVP induces dose-dependent vasodilation of isolated, precontracted, and endothelium-intact rat arteries (pD2 = 5.74). It also induces sustained vasodilation of isolated, precontracted, and endothelium-denuded rat arteries when used at concentrations greater than 1 μM.
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