11-deoxy Prostaglandin E1

A selective EP2 receptor agonist

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库存: 现货

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500ug

￥562.00

450.00

- +
1mg

￥1037.00

830.00

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5mg

￥4287.00

3430.00

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10mg

￥7500.00

6000.00

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货号: ajci21510
CAS: 37786-00-8
别名: 11脱氧前列腺素E1
分子式: C20H34O4
分子量: 338.5
纯度: >98%
溶解度: DMF: >100 mg/ml (from PGE1),DMSO: >50 mg/ml (from PGE1),Ethanol: >50 mg/ml (from PGE1),PBS pH 7.2: >1.6 mg/ml (from PGE1)
储存: Store at -20°C
库存: 现货

Background

11-deoxy Prostaglandin E1 (11-deoxy PGE1) is a synthetic analog of PGE1. Early reports show that it is a selective agonist for the EP2 receptor but effective at much higher concentrations than PGE2. However, later studies show that it is a non-selective agonist of EP receptors and stimulates cAMP release in Jurkat cells with an EC50 of 0.25 uM. 11-deoxy PGE1 also exhibits vasodepressor and bronchodilator responses in guinea pigs. 11-deoxy PGE1 exhibits selectively for the mouse EP3 receptor and is essentially equipotent to PGE1 at this receptor subtype. The Ki values for binding to the mouse EP1, EP2, EP3, and EP4 receptors are 600, 45, 1.1, and 23 nM, respectively.