(+)-Rugulosin

A mycotoxin

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库存: 现货

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数量
500ug

￥1750.00

1400.00

- +
1mg

￥3175.00

2540.00

- +

已选 0 种 0 瓶

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货号: ajci21740
CAS: 23537-16-8
别名: 细皱青霉素+FORM,(+)-Rugulosin
分子式: C30H22O10
分子量: 542.5
纯度: >98%
溶解度: DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble
储存: Store at -20°C; protect from light
库存: 现货

Background

(+)-Rugulosin is a pigment and mycotoxin produced by certain fungi. It inhibits HIV-1 integrase activity with IC50 values of 19 and 25 uM in coupled and strand transfer assays, respectively. It also inhibits ribonuclease H in rat liver by 83% at a concentration of 157 uM and ribonucleases H1, H2, and H3 in T. pyriformis by 100, 99, and 100%, respectively, at a concentration of 313 uM. (+)-Rugulosin leads to hepatic injury and liver cell hyperplasia in mice when administered in the diet. It is cytotoxic to insect cells but not mammalian C6/36, L929, and HepG2 cells (ID50s = 1.2, >200, 23.7, and >200 ug/ml, respectively).