Evatanepag

Evatanepag (CP-533536) 是一种非前列腺素、强效和选择性 EP2 受体激动剂。

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库存: 现货

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促销价

数量
1mg

￥1225.00

980.00

- +
5mg

￥2887.00

2310.00

- +
10mg

￥4087.00

3270.00

- +
50mg

￥12137.00

9710.00

- +
100mg

￥17012.00

13610.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajci22536
CAS: 223488-57-1
别名: 2-[3-[N-(4-叔丁基苄基)-N-(吡啶-3-基磺酰基)氨基甲基]苯氧基]乙酸,CP-533536 free acid
分子式: C25H28N2O5S
分子量: 468.57
纯度: >98%
溶解度: DMSO : ≥ 32 mg/mL (68.29 mM)
储存: Store at -20°C
库存: 现货

Background

Evatanepag (CP-533536) is an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation with EC50 of 0.3 nM.IC50 value: 0.3 nM (EC50)Target PGE2in vitro: CP-533536 is a potent and selective EP2agonist. CP-533536 demonstrates the ability to heal fractures when administered locally as a single dose in rat models of fracture healing. CP-533536 demonstrates excellent in vitro potency against EP2 and selectivity against a broad panel of other targets.

参考文献:
[1]. Cameron KO, et al. Discovery of CP-533536: an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation. Bioorg Med Chem Lett. 2009 Apr 1;19(7):2075-8.