Glucagon receptor antagonists-4

A GCGR antagonist

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1mg

￥325.00

260.00

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5mg

￥762.00

610.00

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10mg

￥1100.00

880.00

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50mg

￥4200.00

3360.00

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100mg

￥7337.00

5870.00

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Background

Glucagon receptor antagonists-4 is a highly potent glucagon receptor antagonist. It displays low in vivo clearance and excellent oral bioavailability in both rats and dogs.

参考文献:
[1]. Guzman-Perez A et al. The design and synthesis of a potent glucagon receptor antagonist with favorable physicochemical andpharmacokinetic properties as a candidate for the treatment of type 2 diabetes mellitus. Bioorg Med Chem Lett, 2013 May 15, 23(10):3051-8.
[2]. Esther C.Y. Lee et al. Identification of a novel conformationally constrained glucagon receptor antagonist. Bioorg Med Chem Lett, 2014 Feb 1, 24(3):839-44.