trans-4,5-epoxy-2(E)-Decenal

A lipid peroxidation by-product

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1mg

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货号: ajci23134
CAS: 134454-31-2
别名: 3-(3-pentyloxiranyl)-2E-propenal
分子式: C10H16O2
分子量: 168.2
纯度: >98%
溶解度: 30mg/mL in DMSO, 30mg/mL in DMF, 30mg/mL in Ethanol
储存: Store at -20°C
库存: 现货

Background

Polyunsaturated fatty acids such as arachidonate and linoeate, while essential to health maintenance, are subject to random peroxidation by ambient oxygen, resulting in fragmented and reactive decomposition products. One prominent autoxidation product of either trilinolein or arachidonic acid is trans-4,5-epoxy-2(E)-decenal. One prominent autoxidation product of either trilinolein or arachidonic acid is trans-4,5-epoxy-2(E)-decenal. This aldehyde is responsible for a pungent metallic flavor of decomposed lipids, with a detection threshold of 1.5 pg/l in air.[1] trans-4,5-epoxy-2(E)-Decenal also reacts with nucleophiles (lysine amino groups) on proteins, leading to loss of cell function and viability.[2] This reactive aldehyde is therefore a useful tool in elucidating the effects of peroxidative damage in experimental models.

Reference:
[1]. Lin, J., Fay, L.B., Welti, D.H., et al. Quantification of key odorants formed by autoxidation of arachidonic acid using isotope dilution assay. Lipids 36(7), 749-756 (2001).
[2]. Zamora, R., and Hidalgo, F.J. Modification of lysine amino groups by the lipid peroxidation product 4,5(E)-epoxy-2(E)-heptenal. Lipids 29, 243-249 (1994).