4-Hydroxyestradiol

A catechol estrogen and minor metabolite of estrogen

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库存: 现货

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500ug

￥962.00

770.00

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1mg

￥1800.00

1440.00

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5mg

￥5562.00

4450.00

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10mg

￥10175.00

8140.00

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货号: ajci23346
CAS: 5976-61-4
别名: 4-羟雌二醇,4-Hydroxy-17β-estradiol
分子式: C18H24O3
分子量: 288.38
纯度: >98%
溶解度: DMF: 20 mg/ml,DMSO: 25 mg/ml,Ethanol: 25 mg/ml,Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
储存: Store at -20°C
库存: 现货

Background

4-Hydroxyestradiol is a catechol estrogen and minor metabolite of estrogen.[1][2]?4-Hydroxyestradiol is formed from estrogen by the cytochrome P450 (CYP) isoform CYP1B1.[2]??Production of 4-hydroxyestradiol is increased in microsomes prepared from human mammary adenocarcinoma and fibroadenoma microsomes compared with microsomes prepared from non-cancerous tissues.[1]?4-Hydroxyestradiol (25 mg/animal) induces renal tumor formation in male hamsters.[3]

Reference:
[1]. Liehr, J.C., and Ricci, M.J. 4-Hydroxylation of estrogens as marker of human mammary tumors. Proc. Natl. Acad. Sci. USA 93(8), 3294-3296 (1996).
[2]. Yager, J.D., and Liehr, J.G. Molecular mechanisms of estrogen carcinogenesis. Annu. Rev. Pharmacol. Toxicol. 36, 203-232 (1996).
[3]. Liehr, J.G., Fang, W.F., Sirbasku, D.A., et al. Carcinogenicity of catechol estrogens in Syrian hamsters. J. Steroid Biochem. 24(1), 353-356 (1986).