5(6)-Carboxyfluorescein (5(6)-FAM)

A fluorescent probe

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1g

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货号: ajci44676
CAS: 72088-94-9
别名: 5(6)-羧基荧光素; 5(6)-FAM; 5-(and-6)-Carboxyfluorescein mixed isomers
分子式: C21H12O7
分子量: 376.32
纯度: >98%
溶解度: DMSO : ≥ 41 mg/mL (108.95 mM)
储存: -20°C, protect from light
库存: 现货

Background

5(6)-Carboxyfluorescein is a mixture of 5-carboxy and 6-carboxy derivatives of fluorescein. It is commonly used to label biomolecules through a reaction involving the carboxyl group.¹ Unlike its succinimidyl ester derivative CFSE , 5(6)-carboxyfluorescein is membrane impermeant. As a result, it can be used in studies of membrane permeability.² 5(6)-Carboxyfluorescein displays excellent fluorescence (excitation/emission at 492/514 nm, respectively), and its excitation maximum closely matches the 488 nm spectral line of argon-ion lasers.

1.Fischer, R., Mader, O., Jung, G., et al.Extending the applicability of carboxyfluorescein in solid-phase synthesisBioconjug. Chem.14(3)653-660(2003) 2.Ferdani, R., Li, R., Pajewski, R., et al.Transport of chloride and carboxyfluorescein through phospholipid vesicle membranes by heptapeptide amphiphilesOrg. Biomol. Chem.5(15)2423-2432(2007)