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  • Malformin A
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Malformin A

A cyclopentapeptide fungal metabolite with diverse biological activities

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Malformin A的二维码
  • 库存: 现货
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  • 包装
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  • 500ug
    ¥2587.00
    2070.00
    - +
  • 1mg
    ¥4362.00
    3490.00
    - +
  • 5mg
    ¥17800.00
    14240.00
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  • 货号: ajci64256
  • CAS: 3022-92-2
  • 别名: Malformin A1
  • 分子式: C23H39N5O5S2
  • 分子量: 529.7
  • 纯度: >98%
  • 溶解度: DMSO: 1 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

Malformin A is a cyclopentapeptide fungal metabolite that has been found in A. niger and has diverse biological activities. It is a plant growth regulator that induces malformations in plant structure. Malformin A inhibits replication of tobacco mosaic virus (TMV) in local lesion and leaf-disc assays (IC50s = 19.7 and 45.4 µg/ml, respectively). It is cytotoxic to NCI-H460, MIA PaCa-2, MCF-7, SF-268, and WI-38 cancer cells (IC50s = 70, 50, 100, 70, and 100 nM, respectively), inhibits proliferation of PC3 and LNCaP cells (IC50s = 130 and 90 nM, respectively), and induces apoptosis and necrosis in PC3 and LNCaP cells. Malformin A also increases the accumulation of reactive oxygen species, decreases the mitochondrial membrane potential, and induces autophagy in PC3 and LNCaP cells. It is toxic to mice when administered intraperitoneally (LD50 = 3.1 mg/kg) but not orally up to doses of 50 mg/kg.

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