15(S)-Fluprostenol

A less active FP receptor agonist

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库存: 现货

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数量
1mg

￥1150.00

920.00

- +
5mg

￥5087.00

4070.00

- +
10mg

￥9025.00

7220.00

- +

已选 0 种 0 瓶

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货号: ajci64808
CAS: 54276-24-3
别名: 曲伏前列素杂质
分子式: C23H29F3O6
分子量: 458.5
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 20 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 5 mg/ml
储存: Store at -20°C
库存: 现货

Background

(+)-15(R)-Fluprostenol isopropyl ester is a prodrug (Travoprost) which is converted by esterase enzymatic activity in the cornea to yield the corresponding free acid. The free acid, (+)-15(R)-fluprostenol, is a potent FP receptor agonist. The 15(R)-epimers of most prostaglandins are about 100 times less potent than the natural, 15(S)-isomers. However, the neighboring phenoxy group at C-16 reverses the absolute configuration at C-15 in the fluprostenol series; hence, 15(S)-fluprostenol is less active as an FP agonist than 15(R)-fluprostenol. The biology of 15(S)-fluprostenol has not been widely studied.