Tamoxifen N-oxide

A metabolite of tamoxifen

原价

￥712-4300

价格

￥ 570-3440

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库存: 现货

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产品引用

货号: ajci64844
CAS: 75504-34-6
别名: 他莫昔芬N-氧化物
分子式: C26H29NO2
分子量: 387.5
纯度: >98%
溶解度: DMF: 20 mg/mL,DMSO: 2 mg/mL,Ethanol: 20 mg/mL,Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/mL
储存: Store at -20°C
库存: 现货

Background

Tamoxifen is a selective estrogen receptor modulator that evokes tissue-dependent effects. Tamoxifen N-oxide is a metabolite of tamoxifen that is produced by the action of flavin-containing monooxygenases. It can be converted back to tamoxifen by cytochrome P450 isoforms and hemoglobin. Like the parent compound, tamoxifen N-oxide can form DNA adducts. Tamoxifen N-oxide is a weak inhibitor of human hydroxysteroid sulfotransferase 2A1 (Kis = 9.1 and 16.9 µM for the sulfonation of dehydroepiandrosterone and pregnenolone, respectively).

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信号通路

生命科学

有机化学

无机化学

材料科学

Tamoxifen N-oxide

Tamoxifen N-oxide详情

Background