11-deoxy-11-methylene Prostaglandin D2

A stable, isosteric PGD2 analog

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库存: 现货

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1mg

￥1187.00

950.00

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5mg

￥5275.00

4220.00

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10mg

￥9362.00

7490.00

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货号: ajci64912
CAS: 100648-29-1
别名: 11deoxy11methylene PGD2
分子式: C21H34O4
分子量: 350.5
纯度: >98%
溶解度: DMF: 100 mg/ml,DMSO: 100 mg/ml,Ethanol: 100 mg/ml,PBS (pH 7.2): 3.75 mg/ml
储存: Store at -20°C
库存: 现货

Background

Prostaglandin D2 is one of the five primary enzymatic prostaglandins derived directly from PGH2 . PGD2 is produced abundantly in the CSF by the lipocalin-type PGD synthase, and in the periphery by myeloid cells including mast cells and basophils by a second, leukocyte-type PGD synthase. PGD2 is chemically unstable, and its use and analysis is complicated by its short in vivo half-life. 11-deoxy-11-methylene PGD2 is a novel, chemically stable, isosteric analog of PGD2 wherein the 11-keto group is replaced by an exocyclic methylene. In the PGE series, the analogous modification leads to a stable, somewhat less potent agonist which embodies the same uterine stimulant and cervical ripening activities as the parent prostaglandin. However, 11-deoxy-11-methylene PGD2 has been reported by one group to be essentially without agonist activity on human platelets, a DP1 receptor assay. The CRTH2-receptor actions of 11-deoxy-11-methylene PGD2 are not yet reported.