(±)14(15)-EpETE

An EPA congener of (±)14(15)-EpETrE with EDHF activity

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库存: 现货

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25ug

￥787.00

630.00

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50ug

￥1487.00

1190.00

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100ug

￥2825.00

2260.00

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500ug

￥12350.00

9880.00

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货号: ajci64962
CAS: 131339-24-7
别名: (±)14,15 EEQ, (±)14,15epoxy Eicosatetraenoic Acid
分子式: C20H30O3
分子量: 318.5
纯度: >98%
溶解度: DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 1 mg/ml
储存: Store at -20°C
库存: 现货

Background

EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators. Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids, produces epoxides such as (±)14(15)-EpETrE which are prime candidates for the actual active mediator. However, the CYP450 metabolites of eicosapentaenoic acid and docosahexaenoic acid have been little studied relative to arachidonate epoxygenase metabolites. (±)14(15)-EpETE is the ω-3 homolog of 14(15)-EpETrE, derived via epoxidation of the 14,15-double bond of EPA. The EDHF activity of (±)14(15)-EpETE has not yet been determined.