DL-Mevalonolactone

A precursor in the mevalonate pathway

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250mg

￥775.00

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1190.00

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1g

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货号: ajci65232
CAS: 674-26-0
别名: 甲瓦龙酸内酯,(±)-Mevalonolactone; Mevalolactone
分子式: C6H10O3
分子量: 130.1
纯度: >98%
溶解度: DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 20 mg/ml,PBS (pH 7.2): 0.5 mg/ml
储存: Store at -20°C
库存: 现货

Background

DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential (?Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling[1][2].

参考文献:
[1]. Domingos SR, et al. On the structural intricacies of a metabolic precursor: Direct spectroscopic detection of water-induced conformational reshaping of mevalonolactone. J Chem Phys. 2017 Sep 28;147(12):124310.
[2]. Cecatto C, et al. Mevalonolactone disrupts mitochondrial functions and induces permeability transition pore opening in rat brain mitochondria: Implications for the pathogenesis of mevalonic aciduria. Neurochem Int. 2017 Sep;108:133-145.