5-(Hydroxymethyl)-2'-deoxyuridine

A nucleoside analog

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库存: 现货

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数量
10mg

￥400.00

320.00

- +
25mg

￥975.00

780.00

- +
50mg

￥1850.00

1480.00

- +
100mg

￥3150.00

2520.00

- +

已选 0 种 0 瓶

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货号: ajci65296
CAS: 5116-24-5
别名: 5-羟甲基脱氧尿苷
分子式: C10H14N2O6
分子量: 258.2
纯度: >98%
溶解度: DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 25 mg/ml,PBS (pH 7.2): 10 mg/ml
储存: Store at -20°C
库存: 现货

Background

5-(Hydroxymethyl)-2'-deoxyuridine is a nucleoside analog with anticancer and antiviral activities. It inhibits the replication of murine S180 lung carcinoma cells and Ehrlich ascites mammary carcinoma cells (ED50s = 8.5 and 4 μM, respectively) and multiple human leukemia cell lines (IC50s = 1.7-5.8 μM). 5-(Hydroxymethyl)-2'-deoxyuridine acts synergistically with 5-fluorouracil against HT-29, HCT116, PANC-1, and EKVX cancer cells with no effect on WI38 embryonic lung fibroblasts. It inhibits herpes simplex virus type 1 (HSV-1) pyrimidine 2'-deoxyribonucleoside kinase (Ki = 3.5 μM) and reduces HSV-1 viral titer to 0.05% of the control at a concentration of 200 μM. 5-(Hydroxymethyl)-2'-deoxyuridine is also a DNA adduct, formed in response to oxidative stress, that is found in hepatic DNA of rats treated with gamma irradiation, diethylnitrosamine, 2-acetylaminofluorene, and ciprofibrate .