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  • C-178的结构
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C-178

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¥900.00-4500.00
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585.00-2925.00
C-178的二维码

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C-178 is a covalent inhibitor of STING.

货号:ajci65382
CAS:329198-87-0
分子式:C17H10N2O5
分子量:322.3
纯度:98%
存储:Store at -20°C
库存:现货

Background:

C-178, a covalent inhibitor of STING, binds to Cys91, potently and selectively suppresses the STING responses elicited by distinct bona fide activators in mouse but not human. C-178 significantly reduces STING-, but not RIG-I- or TBK1-, mediated IFN-β reporter activity. C-178 blocks palmitoylation (PMA)-induced clustering of STING; inhibits the CMAinduced phosphorylation of TBK1 (downstream protein kinase of STING)[1].

参考文献:

[1]. Haag SM, et al. Targeting STING with covalent small-molecule inhibitors. Nature. 2018 Jul;559(7713):269-273.

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