C-178

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

可选规格

包装

价格

促销价

数量
5mg

￥900.00

585.00

- +
10mg

￥1500.00

975.00

- +
25mg

￥2500.00

1625.00

- +
50mg

￥4500.00

2925.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

C-178 is a covalent inhibitor of STING.

货号：ajci65382
CAS：329198-87-0
分子式：C17H10N2O5
分子量：322.3
纯度：98%
存储：Store at -20°C
库存：现货

Background:

C-178, a covalent inhibitor of STING, binds to Cys91, potently and selectively suppresses the STING responses elicited by distinct bona fide activators in mouse but not human. C-178 significantly reduces STING-, but not RIG-I- or TBK1-, mediated IFN-β reporter activity. C-178 blocks palmitoylation (PMA)-induced clustering of STING; inhibits the CMAinduced phosphorylation of TBK1 (downstream protein kinase of STING)[1].

参考文献：

[1]. Haag SM, et al. Targeting STING with covalent small-molecule inhibitors. Nature. 2018 Jul;559(7713):269-273.