9(Z),11(E),13(E)-Octadecatrienoic Acid methyl ester

A polyunsaturated fatty acid methyl ester

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库存: 现货

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1mg

￥937.00

750.00

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5mg

￥4162.00

3330.00

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10mg

￥7387.00

5910.00

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货号: ajci65662
CAS: 4175-47-7
别名: 9顺,11反,13反-十八碳三烯酸甲酯
分子式: C19H32O2
分子量: 292.5
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 100 mg/ml
储存: Store at -20°C
库存: 现货

Background

9Z,11E,13E-octadecatrienoic acid (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil. α-ESA is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats. It has shown potential as a tumor growth suppressor. In colon cancer Caco-2 cells, α-ESA induced apoptosis through up-regulation of GADD45, p53, and PPARγ. In DLD-1 cells supplemented with α-ESA, apoptosis was induced via lipid peroxidation with an EC50 of 20 µM. It also inhibits DNA polymerases and topoisomerases with IC50s ranging from ~5-20 µM for different isoforms of the enzymes. α-ESA methyl ester is a neutral, more lipid soluble form of the free acid.