α-Muricholic Acid

A murine-specific primary bile acid

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库存: 现货

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1mg

￥1962.00

1570.00

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5mg

￥6837.00

5470.00

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10mg

￥12562.00

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货号: ajci65678
CAS: 2393-58-0
别名: 5β-Cholanic Acid-3α,6β,7α-triol
分子式: C24H40O5
分子量: 408.6
纯度: >98%
溶解度: 20mg/mL in ethanol, or in DMSO, 30mg/mL in DMF
储存: Store at -20°C
库存: 现货

Background

α-Muricholic acid is a murine-specific primary bile acid.[1]? Dietary administration of soybean protein decreases fecal levels of α-muricholic acid in mice with high-fat diet-induced obesity which correlates with increases in fecal Clostridium cluster XIVa, a major producer of secondary bile acids.[2] [3] Plasma, liver, and muscle levels of α-muricholic acid are increased in mice switched from a high-fat to low-fat diet.[4]

Reference:
[1]. Eyssen, H.J., Parmentier, G.G., and Mertens, J.A. Sulfate bile acids in germ-free and conventional mice. Eur. J. Biochem. 66(3), 507-514 (1976).
[2]. Uehara, T., Xi Peng, X., Bennett, B., et al. c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation. Transplantation 78(3), 324-332 (2004).
[3]. Watanabe, K., Igarashi, M., Li, X., et al. Dietary soybean protein ameliorates high-fat diet-induced obesity by modifying the gut microbiota-dependent biotransformation of bile acids. PLoS One 13(8), e0202083 (2018).
[4]. La Frano, M.R., Hernandez-Carretero, A., Weber, N., et al. Diet-induced obesity and weight loss alter bile acid concentrations and bile acid-sensitive gene expression in insulin target tissues of C57BL/6J mice. Nutr. Res. 46, 11-21 (2017).