Eicosapentaenoic Acid ethyl ester

An ω-3 fatty acid ethyl ester

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库存: 现货

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10mg

￥375.00

300.00

- +
50mg

￥650.00

520.00

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100mg

￥1100.00

880.00

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500mg

￥3775.00

3020.00

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货号: ajci65868
CAS: 86227-47-6
别名: 顺-二十碳五烯酸乙酯,EPA ethyl ester; Ethyl eicosapentaenoate
分子式: C22H34O2
分子量: 330.5
纯度: >98%
溶解度: DMF: 100 mg/ml,DMSO: 100 mg/ml,Ethanol: 100 mg/ml,PBS (pH 7.2): 0.15 mg/ml
储存: Store at -20°C, stored under nitrogen
库存: 现货

Background

Fish oils in the diet have anti-inflammatory and cardiovascular benefits due to an abundance of ω-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid (EPA). EPA ethyl ester is a stabilized ethyl ester form of this ω-3 C20:5 PUFA. EPA competitively inhibits the metabolism of (ω-6) arachidonic acid by cyclooxygenase enzymes, suggesting that EPA ethyl ester may also directly modulate the actions of enzymes involved in fatty acid metabolism. In addition, dietary EPA ethyl ester in rats increases fatty acid β-oxidation enzyme levels, indicating that EPA ethyl ester may alter the expression of genes related to fatty acid metabolism. Consistent with this concept, dietary supplementation with EPA ethyl ester in rats also down-regulates lipogenic genes, and decreases plasma cholesterol and triglyceride levels. Also, in rats fed a high-fat diet, supplementation with EPA ethyl ester blocks induced insulin resistance and corrects changes in adiponectin levels and TNF-α expression.