Tafluprost (free acid)

A PGF derivative similar to latanoprost free acid

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库存: 现货

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数量
1mg

￥1925.00

1540.00

- +
5mg

￥8600.00

6880.00

- +
10mg

￥15125.00

12100.00

- +
25mg

￥33100.00

26480.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajci65974
CAS: 209860-88-8
别名: 他氟前列素酸,AFP-172
分子式: C22H28F2O5
分子量: 410.5
纯度: >98%
溶解度: DMF: 30 mg/ml,DSMO: 30 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 3 mg/ml
储存: Store at -20°C
库存: 现货

Background

A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma. Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects. Alternatively, it was recently reported that analogs incorporating a 15-deoxy-15,15-difluoro modification also had a favorable ophthalmic activity profile. Tafluprost is a 2-series, 16-phenoxy analog of PGF2α with the 15,15-difluoro substitution. Tafluprost (free acid) is a very potent FP receptor agonist, with a Ki of 0.4 nM. The ester prodrug forms of tafluprost are also potent ocular hypotensives in monkeys.