Isogarcinol

A natural benzophenone that has immunosuppressant actions

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库存: 现货

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数量
1mg

￥637.00

510.00

- +
5mg

￥2887.00

2310.00

- +
10mg

￥5100.00

4080.00

- +
25mg

￥11162.00

8930.00

- +

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货号: ajci66044
CAS: 71117-97-0
别名: Cambogin
分子式: C38H50O6
分子量: 602.8
纯度: >98%
溶解度: DMF: 25 mg/ml,DMSO: 25 mg/ml,DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml,Ethanol: 20 mg/ml
储存: Store at -20°C, protect from light
库存: 现货

Background

Isogarcinol is a natural polyisoprenylated benzophenone first isolated from plant species in the genus Garcinia. It has immunosuppressant actions, inhibiting the protein phosphatase calcineurin (IC50 = 36 µM) and suppressing the proliferation of T cells. Oral administration of isogarcinol in mice decreases delayed type hypersensitivity, prolongs graft survival in allogeneic skin transplants, suppresses inflammation in collagen-induced arthritis, and reduces clinical symptoms in experimental autoimmune encephalomyelitis. Isogarcinol inhibits the proliferation of HL-60 and PC-3 cancer cells (IC50s = 4 and 8 µg/ml, respectively) through cell cycle arrest and apoptosis.