Glycohyocholic Acid

A glycine-conjugated form of hyocholic acid

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500ug

￥1012.00

810.00

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1mg

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1540.00

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5mg

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10mg

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货号: ajci66066
CAS: 32747-08-3
别名: 甘氨猪胆酸钠盐,Glycine Hyocholate
分子式: C26H43NO6
分子量: 465.6
纯度: >98%
溶解度: 20mg/mL in ethanol, 30mg/mL in DMSO, or in DMF
储存: Store at -20°C
库存: 现货

Background

Glycohyocholic acid (GHCA) is a glycine-conjugated form of the primary bile acid hyocholic acid .[1] GHCA is upregulated 6.6-fold in the serum of patients with cirrhosis induced by hepatitis C virus (HCV) compared to healthy controls.[2] Plasma levels of GHCA increase in patients who are no longer diabetic following gastric bypass surgery.[3]

Reference:
[1]. Guo, L., Milburn, M.V., Ryals, J.A., et al. Plasma metabolomic profiles enhance precision medicine for volunteers of normal health. Proc. Nat. Acad. Sci. USA 112(35), E4901-E4910 (2015).
[2]. Fitian, A.I., Nelson, D.R., Liu, C., et al. Integrated metabolomic profiling of hepatocellular carcinoma in hepatitis C cirrhosis through GC/MS and UPLC/MS-MS. Liver Int. 34(9), 1428-1444 (2014).
[3]. Yu, H., Ni, Y., Bao, Y., et al. Chenodeoxycholic acid as a potential prognostic marker for roux-en-Y gastric bypass in chinese obese patients. J. Clin. Endocrinol. Metab. 100(11), 4222-4230 (2015).