DOPAL

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

可选规格

包装

价格

促销价

数量
5mg

￥1000.00

800.00

- +
10mg

￥1813.00

1450.00

- +
25mg

￥4000.00

3200.00

- +
50mg

￥6250.00

5000.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

DOPAL is an aldehyde product of the oxidative deamination of dopamine by monoamine oxidase.

货号：ajci66132
CAS：5707-55-1
分子式：C8H8O3
分子量：152.1
纯度：90%
存储：Store at -20°C
库存：现货

Background:

DOPAL is an aldehyde product of the oxidative deamination of dopamine by monoamine oxidase.[1] It can be further oxidized to 3,4-dihydroxyphenylacetic acid (DOPAC) by aldehyde dehydrogenase (ALDH) and, to a lesser extent reduced to 3,4-dihydroxyphenyl ethanol (DOPET). DOPAL is toxic to neurons.[2],[3] It can also oligomerize and precipitate α-synuclein, an event associated with Parkinson's disease.[2] Mice lacking cytosolic and mitochondrial forms of ALDH display increased levels of DOPAL as well as neurodegeneration and motor dysfunction characteristic of Parkinson’s disease.[4]

Reference:
[1]. Jinsmaa, Y., Florang, V.R., Rees, J.N., et al. Products of oxidative stress inhibit aldehyde oxidation and reduction pathways in dopamine catabolism yielding elevated levels of a reactive intermediate. Chemical Research in Toxicology 22(5), 835-841 (2009).
[2]. Goldstein, D.S., Sullivan, P., Holmes, C., et al. Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson’s disease. Journal of Neurochemistry 126(5), 591-603 (2013).
[3]. Panneton, W.M., Kumar, V.B., Gan, Q., et al. The neurotoxicity of DOPAL: Behavioral and stereological evidence for its role in Parkinson disease pathogenesis. PLoS One 5(12), e15251 (2010).
[4]. Wey, M.C.Y., Fernandez, E., Martinez, P.A., et al. Neurodegeneration and motor dysfunction in mice lacking cytosolic and mitochondrial aldehyde dehydrogenases: implications for Parkinson’s disease. PLoS One 7(2), e31522 (2012).