16-phenoxy tetranor Prostaglandin F2α methyl ester

Lipophilic analog of 16-phenoxy tetranor PGF2α

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500ug

￥912.00

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1mg

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货号: ajci66164
CAS: 51638-90-5
别名: 16phenoxy tetranor PGF2α
分子式: C23H32O6
分子量: 404.5
纯度: >98%
溶解度: DMF: 100 mg/ml,DMSO: 100 mg/ml,Ethanol: 100 mg/ml,PBS (pH 7.2): .5 mg/ml
储存: Store at -20°C
库存: 现货

Background

Prostaglandin F2α (PGF2α) drives luteolysis and smooth muscle contraction by activating the FP receptor. Stable, lipophilic analogs of PGF2α are used to modulate luteolysis and treat glaucoma. 16-phenoxy tetranor Prostaglandin F2α (16-phenoxy tetranor PGF2α) is a metabolically stable form of PGF2α containing a 16-phenoxy group at the ω-terminus. It binds to the FP receptor on ovine luteal cells with much greater affinity (440%) than PGF2α. 16-phenoxy tetranor PGF2α methyl ester is a lipophilic analog of 16-phenoxy tetranor PGF2α. Methyl esters of PGs serve as prodrugs, as they are efficiently hydrolyzed in certain tissues to generate the bioactive free acid.