10(S),17(S)-DiHDHA

A DHA derivative with anti-inflammatory and anti-platelet activity

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库存: 现货

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25ug

￥3062.00

2450.00

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50ug

￥5450.00

4360.00

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100ug

￥10325.00

8260.00

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货号: ajci66184
CAS: 871826-47-0
别名: 10(S),17(S)-DiHDoHE; PDX
分子式: C22H32O4
分子量: 360.5
纯度: >98%
溶解度: 0.1 M Na2CO3: 1 mg/ml,DMF: Miscible,DMSO: Miscible,Ethanol: Miscible,PBS (pH 7.2): 0.5 mg/ml
储存: Store at -20°C
库存: 现货

Background

Protectin D1 (also known as neuroprotectin D1 when produced in neuronal tissues) is a DHA-derived dihydroxy fatty acid that exhibits potent protective and anti-inflammatory activities. 10(S),17(S)-DiHDHA is a DHA metabolite, also referred to as protectin DX (PDX). It is produced by an apparent double lipoxygenase (LO)-mediated reaction in murine peritonitis exudates, in suspensions of human leukocytes, or by soybean 15-LO incubated with DHA. It differs from protectin D1 with respect to the stereochemistry of the C-10 hydroxyl and the double bond configuration at the 13 and 15 positions. 10(S),17(S)-DiHDHA blocks neutrophil infiltration in murine peritonitis by 20-25% at a dose of 1 ng/mouse. It also inhibits platelet activation by both impairing thromboxane (TX) synthesis and TX receptor activation.