15(R)-17-phenyl trinor Prostaglandin F2α

The 15(R)-isomer of the activated, free acid form of bimatoprost

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库存: 现货

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1mg

￥1062.00

850.00

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5mg

￥4725.00

3780.00

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10mg

￥8387.00

6710.00

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货号: ajci66218
CAS: 41639-71-8
别名: 贝美前列素杂质
分子式: C23H32O5
分子量: 388.5
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 25 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 1 mg/ml
储存: Store at -20°C
库存: 现货

Background

17-phenyl trinor Prostaglandin F2α N-ethyl amide (17-phenyl trinor PGF2α) is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name 17-phenyl trinor PGF2α ethyl amide. Investigations in our lab have shown that 17-phenyl trinor PGF2α ethyl amide is converted by an amidase enzymatic activity in the human cornea to yield the corresponding free acid, with a conversion rate of about 25 µg/cornea/24 hours. The free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist. 15(R)-17-phenyl trinor PGF2α is the 15-epi, or "unnatural" isomer of this active free acid metabolite. It has much diminished FP receptor-mediated activity, which is generally 1.5 to 2 logs less than the 15(S)-isomer. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity.