12-epi Leukotriene B4

LTB4 isomer with weak agonist activity at BLT1 and BLT2 receptors

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库存: 现货

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25ug

￥2775.00

2220.00

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50ug

￥5225.00

4180.00

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100ug

￥9900.00

7920.00

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货号: ajci66488
CAS: 83709-73-3
别名: 12<span class=\foreign\>epi</span> LTB4
分子式: C20H32O4
分子量: 336.5
纯度: >98%
溶解度: DMF: >50 mg/ml, DMSO: >50 mg/ml, Ethanol: >50 mg/ml, PBS pH 7.2: >1 mg/ml
储存: Store at -20°C, protect from light
库存: 现货

Background

Leukotriene B4 (LTB4) compounds are produced by both enzymatic and non-enzymatic processes. The products of enzymatic origin, via Leukotriene A4 (LTA4) hydrolase, are stereospecifically 12(R). Non-enzymatic hydrolysis products are 50:50 mixtures at C-12, but are almost exclusively trans at C-6. Thus, the non-enzymatic hydrolysis product of LTA4 is 6-trans-12-epi LTB4. 12-epi LTB4 is an isomer which would not be expected to occur in either non-enzymatic hydrolysis products, or in the enzymatic products of LTA4 hydrolase. Compared to LTB4, 12-epi LTB4 has significantly reduced activity for the LTB4 receptor on human neutrophils (IC50 of 7.5 mM), and on guinea pig lung membranes with a (Ki of 4.7 mM). 12-epi LTB4 is an weak agonist at both the recombinant human BLT1 and BLT2 receptors, requiring approximately 10 mM for full activation of the receptor.