20-ethyl Prostaglandin F2α

An analog of PGF2α with an extended ω-chain

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库存: 现货

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1mg

￥1062.00

850.00

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5mg

￥4725.00

3780.00

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10mg

￥8387.00

6710.00

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货号: ajci66734
CAS: 36950-85-3
别名: ICI 74205, 20ethyl PGF2α
分子式: C22H38O5
分子量: 382.5
纯度: >98%
溶解度: DMF: 33 mg/ml,DMSO: 14 mg/ml,Ethanol: 33 mg/ml,PBS (pH 7.2): 3 mg/ml
储存: Store at -20°C
库存: 现货

Background

20-ethyl Prostaglandin F2α (20-ethyl PGF2α) is an analog of PGF2α in which the ω-chain has been extended by the addition of two more methylene carbon atoms. It is therefore a modified version of the clinically approved glaucoma medication unoprostone. Unoprostone also contains lower side chain modifications (13,14-dihydro-15-keto) which severely limit its affinity for FP receptors, contributing to its lack of potency as a medication. 20-ethyl PGF2α retains the natural 15(S) allylic hydroxyl in the lower side chain, which may improve its potency as an intraocular hypotensive agent compared to unoprostone. The 2 carbon extension in 20-ethyl-PGF2α increases the Ki (120 nM) for the FP receptor from bovine corpus luteum only about 2.5-fold compared to PGF2α (50 nM). In vivo effects may be prolonged using 20-ethyl PGF2α, as the activity of 15-hydroxy PGDH using 20-ethyl PGF2α as a substrate is only 35% of the activity observed with PGF2α.