A precusor of sialic acid
Sialic acids, commonly present as terminal carbohydrates on glycoconjugates, are essential for a variety of cellular functions including cell adhesion and signal recognition as well as the formation and progression of tumors.1 Disruption of sialic acid biosynthesis can result in severe glomerular proteinuria or neuromuscular disorders such as hereditary inclusion body myopathy (HIBM).2 N-
1.Schwarzkopf, M., Knobeloch, K.P., Rohde, E., et al.Sialylation is essential for early development in miceProc. Natl. Acad. Sci. USA99(8)5267-5270(2002) 2.Galeano, B., Klootwijk, R., Manoli, I., et al.Mutation in the key enzyme of sialic acid biosynthesis causes severe glomerular proteinuria and is rescued by N-acetylmannosamineJ. Clin. Invest.117(6)1585-1594(2007) 3.Gagiannis, D., Gossrau, R., Reutter, W., et al.Engineering the sialic acid in organs of mice using N-propanoylmannosamineBiochim. Biophys. Acta1770297-306(2007)
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