EMPO

A free radical spin trap

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5mg

￥712.00

570.00

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10mg

￥1375.00

1100.00

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25mg

￥2887.00

2310.00

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50mg

￥5025.00

4020.00

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货号: ajci66822
CAS: 61856-99-3
别名: 5-(Ethoxycarbonyl)-5-methyl-1-Pyrroline-N-Oxide
分子式: C8H13NO3
分子量: 171.2
纯度: >98%
溶解度: 15 mg/ml in DMSO, 30 mg/ml in DMF, 30 mg/ml in Ethanol
储存: Store at -20°C
库存: 现货

Background

EMPO is a hydrophilic cyclic nitrone analog of the free radical spin trap DMPO . The EMPO-superoxide adduct (EMPO-OOH) exhibits an ESR spectrum that is similar to the DMPO-OOH spectrum. [1] However, the EMPO-OOH adduct is about 5-8 times more stable (t1/2 = 4.8 - 8.6 min) and does not spontaneously decay to the hydroxyl adduct, making spectral interpretation less difficult. [1][2][3]?

Reference:
[1]. Olive, G., Mercier, A., Le Moigne, F., et al. 2-ethoxycarbonyl-2-methyl-3,4-dihydro-2H-pyrrole-1-oxide: evaluation of the spin trapping properties. Free Radic. Biol. Med. 28(3), 403-408 (2000).
[2]. Stolze, K., Udilova, N., and Nohl, H. Spin adducts of superoxide, alkoxyl, and lipid-derived radicals with EMPO and its derivatives. Biol. Chem. 383(5), 813-820 (2002).
[3]. Zhang, H., Joseph, J., Vasquez-Vivar, J., et al. Detection of superoxide anion using an isotopically labeled nitrone spin trap: Potential biological applications. FEBS Lett. 473(1), 58-62 (2000).