A natural kavalactone
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Methysticin is a natural kavalactone from the kava plant, P. methysticum. It enhances the binding of bicuculline methochloride at the γ-aminobutyric acid (GABA) receptor GABAA at 0.1 µM. Methysticin inhibits the cytochrome P450 (CYP) isoforms CYP2C9 and CYP2D6.
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