15(R)-Prostaglandin D2

A potent, selective DP2 receptor agonist

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1mg

￥1775.00

1420.00

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5mg

￥7887.00

6310.00

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货号: ajci67074
CAS: 59894-05-2
别名: 15(R)PGD2
分子式: C20H32O5
分子量: 352.5
纯度: >98%
溶解度: DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.4): 1 mg/ml
储存: Store at -20°C
库存: 现货

Background

Many of the effects of prostaglandin D2 (PGD2) are transduced via a traditional 7-transmembrane GPCR, the DP1 receptor. However, in certain leukocytes and other immune cells, a second PGD2 receptor referred to as the CRTH2 or DP2 receptor has been cloned and characterized. 15(R)-15-methyl PGD2 is a surprisingly potent agonist at the DP2 receptor, being about 5 times more potent than PGD2 itself. 15(R)-PGD2 has the potential to be produced endogenously as a natural ligand for DP2, unlike the synthetic 15-methyl analogs. In preliminary reports, 15(R)-PGD2 has also been reported to be a potent and selective DP2 receptor agonist.