8-iso-15-keto Prostaglandin F2α

A metabolite of 8-iso PGF2α with vasoconstrictor activity

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库存: 现货

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100ug

￥512.00

410.00

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500ug

￥1550.00

1240.00

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1mg

￥2850.00

2280.00

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货号: ajci67094
CAS: 191919-01-4
别名: 8<span class=\foreign\>epi</span>15keto PGF2α, 815keto PGF2α
分子式: C20H32O5
分子量: 352.5
纯度: >98%
溶解度: 10 mM Na2CO3: >6.5 mg/ml (from PGF2a),DMF: >100 mg/ml (from PGF2a),DMSO: >100 mg/ml (from PGF2a),Ethanol: >100 mg/ml (from PGF2a),PBS pH 7.2: >10 mg/ml (from PGF2a)
储存: Store at -20°C
库存: 现货

Background

8-iso-15-keto Prostaglandin F2α (8-iso-15-keto PGF2α) is a metabolite of the isoprostane 8-iso PGF2α in rabbits, monkeys, and humans. 8-isoprostane (8-iso PGF2α) is a prostaglandin-like product of non-specific lipid peroxidation. In both humans and monkeys, exogenously infused 8-iso PGF2α is converted primarily to metabolites having 2 or 4 carbon atoms removed from the top side chain by β-oxidation. A similar pattern is observed when tritiated 8-iso PGF2α is infused into rabbits. Early in the infusion (within 1-2 minutes) 8-iso -15-keto PGF2α was a major component of the metabolite profile, which was comprised mostly of unmetabolized 8-iso PGF2α. 8-iso -15-keto PGF2α is a vasoconstrictor when tested on the rat isolated thoracic aorta, acting via the TP (thromboxane) receptor.