Theaflavin 3,3'-digallate

A polyphenol with diverse biological activities

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
1mg

￥637.00

510.00

- +
5mg

￥2425.00

1940.00

- +
10mg

￥4062.00

3250.00

- +
25mg

￥8800.00

7040.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajci67388
CAS: 30462-35-2
别名: 茶黄素-3,3'-双没食子酸; TF-3; ZP10
分子式: C43H32O20
分子量: 868.7
纯度: >98%
溶解度: DMF: 25 mg/ml,DMF:PBS(pH 7.2)(1:6): 0.14 mg/ml,DMSO: 10 mg/ml,Ethanol: 10 mg/ml
储存: Store at -20°C, sealed storage, away from moisture and light
库存: 现货

Background

Theaflavin-3,3'-digallate (TFDG) is a major polyphenol found in black tea with diverse biological activities. It has antioxidant activity, inhibiting the formation of superoxide radicals, singlet oxygen, hydrogen peroxide, and hydroxyl radicals in vitro (IC50s = 26.7, 0.83, 0.39, and 25.07 µmol/L, respectively). It also reduces hydroxyl radical-induced damage to plasmid DNA. TFDG (12.5-50 µM) prevents LPS-induced release of TNF-α, IL-1β, and IL-6, expression of JNK and p38, and nuclear translocation of NF-κB in RAW 264.7 cells. In vivo, TFDG reduces serum levels of TNF-α, IL-1β, and IL-6 and decreases pulmonary edema, pulmonary congestion, and thickening of the alveolar wall in a mouse model of LPS-induced acute lung injury. It also inhibits osteoclast formation, polarization, and osteoclastic bone resorption in vitro and reduces titanium particle-induced bone erosion and the number of mature osteoclasts in mice in a dose-dependent manner.