15(S)-Fluprostenol isopropyl ester

An unnatural C-15 epimer of travoprost

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
1mg

￥1400.00

1120.00

- +
5mg

￥6287.00

5030.00

- +
10mg

￥11162.00

8930.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajci67420
CAS: 1420791-14-5
别名: 15（S）-氟丁烯醇异丙酯
分子式: C26H35F3O6
分子量: 500.6
纯度: >98%
溶解度: DMF: 15 mg/ml,DMSO: 12 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:1): 1 mg/ml
储存: Store at -20°C
库存: 现货

Background

15(S)-Fluprostenol isopropyl ester (15(S)-Flu-Ipr) is the unnatural C-15 epimer of Travoprost. Travoprost is the Alcon trade name for fluprostenol isopropyl ester, (Flu-Ipr) an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug. Flu-Ipr is a prodrug which is converted by esterase enzymatic activity in the cornea to yield the corresponding free acid. The free acid, fluprostenol, is a potent FP receptor agonist. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity. Although data is currently not available for the activity of 15(S)-Flu-Ipr, inversion of the stereochemistry at the 15 position of ocular hypotensive prostaglandins generally lowers the potency approximately 100 fold.