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  • trans-Urocanic Acid
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trans-Urocanic Acid

A major epidermal chromophore

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trans-Urocanic Acid的二维码
  • 库存: 现货
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  • 1g
    ￥450.00
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  • 货号: ajci67460
  • CAS: 3465-72-3
  • 别名: 尿刊酸,(E)-Urocanic acid; trans-UCA
  • 分子式: C6H6N2O2
  • 分子量: 138.1
  • 纯度: >98%
  • 溶解度: DMF: 3 mg/ml,DMSO: 15 mg/ml,PBS (pH 7.2): 0.3 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

trans-Urocanic acid is a major epidermal chromophore for the immunosuppressive effects of UV radiation that is produced in mammalian stratum corneum by the action of histidine ammonialyase on L-histidine. It contributes to the acidification of the surface of the stratum corneum, and its function has been proposed as that of an endogenous sunscreen, endowing a low-level of protection (SPF ~ 1.5) against UV-induced DNA damage and excessive keratinocyte apoptosis. Upon UVB exposure, trans-urocanic acid is converted to the cis isomer, which is known to activate regulatory T cells.

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